The article assesses the process of development of relations between Kazakhstan and Uzbekistan, describes the impact on bilateral relations of current events in international relations. Kazakh-Uzbek relations have a historical character, emphasize the common position between the two countries, the importance of common interests. The author, assessing the prospects for cooperation between the two countries, first of all focused on the influence of external factors. He gave data on the events taking place in modern international relations, analyzed the relations between Kazakhstan and Uzbekistan in the new conditions.